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In fact, one drug company just submitted an application to the Food and Drug Administration for approval of its purified CBD drug, which seems to help kids with two different kinds of seizure disorders - Lennox-Gastaut syndrome and Dravet syndrome. "It may be that it has broader effects than that, but most studies have been for these forms of epilepsy," says Weiss.
But when it comes to other health issues and diseases, like cancer, she says most of the data come from cell culture and animal studies. "And thats sort of the rub here - people may make claims based on research from cell and animal studies, but weve actually had a lot of things work in cell cultures that dont work when you give them to people."
But still, there are lots of people who advocate for CBD after it helped them get better.
Dr. Junella Chin, an integrative cannabis physician and founder of MedLeafRx, told BuzzFeed Health in an email about one patient who has benefited from medical marijuana and CBD.
"Andrew, a 57-year-old man came into my office after sustaining a head injury from falling backwards off an 8-foot ladder. He started developing chronic migraines, brain fog, fatigue, nausea - felt dizzy all the time. Then he began to develop a hypersensitivity of his scalp. Simple daily routines, such as riding in a car, were an awful experience; just driving over a small bump would send stabbing pain through his skull," she said. After he started vaping medical marijuana on the recommendation of his son (in the beginning he used THC and CBD, but now just CBD), his pain and migraines are more manageable, she says.
Similarly, shes treated a patient with amyotrophic lateral sclerosis (ALS, or Lou Gehrigs disease), who was experiencing fatigue, depression, and severe anxiety. The patient improved after using CBD - enough to stop taking prescribed meds for these problems. And when it comes to patients with other kinds of pain and inflammation, she says that *anecdotally* salves, creams, and transdermal patches have worked for them, even though "these products have not gone through rigorous human clinical trials that are double blind, randomized, and controlled" - aka the "gold standard" of scientific experiments because they are seen as having the least amount of bias.
Unfortunately, with marijuana still being illegal on a federal level, its pretty hard to find out if any of this anecdotal evidence can apply to the broader population.
And by illegal, we mean that marijuana is considered a schedule I substance under the Controlled Substances Act of 1970. That basically means marijuana is considered to have no currently accepted medical use and a high potential for abuse. (Other drugs classified as schedule I include heroin, ecstasy, and LSD.) Its this scheduling that makes it difficult to get the research done.
"The research isnt the easiest thing to do because CBD, being a component of the marijuana plant, still falls under schedule I, which means there are many administrative burdens to doing this kind of research. … The DEA is the main thing. You have to get a schedule I license, and these things are very time consuming," says Weiss. "We hear from the research community that they do struggle sometimes with getting a schedule I license."
Researchers need to obtain a schedule I license to research and really understand CBD.
Because its relatively difficult to obtain a schedule 1 license, its hard for researchers to gain a basic understanding of CBD - like what the right dose is for a therapeutic effect, how the dosage should change when administered orally versus transdermally, and whether there are interactions between CBD and other prescription drugs. That information is necessary before its possible to find out what diseases CBD might actually help. All of this is needed for the FDA to approve a drug to treat a medical condition, Weiss says. "Were really not sure of any of the purported effects; what the mechanisms are." CB
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