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Liraglutide 99% white podwer CAS 204656-20-2 It reduces meal-related hyperglycemia (for 24 hours aft


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Function and Usage of Liraglutide 204656-20-2
Liraglutide improves control of blood glucose.It reduces meal-related hyperglycemia (for 24 hours after administration) by increasing insulin secretion (only) when required by increasing glucose levels, delaying gastric emptying, and suppressing prandial glucagon secretion.



Liraglutide is a transparent, colorless solution. The dosage form is subcutaneous injection. After more than 10 years of research and development, Lilalutide has many functions such as promoting islet cell regeneration, reducing blood sugar, weight loss and protecting the cardiovascular system. The trade name Victoza is used to treat type 2 diabetes, and the trade name Saxenda is used to treat chronic obesity as a supplement to diet control and physical training. Liraglutide is an acylated human glucagon like peptide-1 (GLP-1) receptor agonist with 97% amino acid sequence homology with endogenous human GLP-1 (7-37), retaining all the biological activity of GLP-1 and exhibiting GLP-1 receptor agonist activity. By expressing recombinant DNA in brewing yeast, its molecular structure differs from natural GLP-1 molecules by only one amino acid. The structure only modifies GLP-1 in two parts: the 34th lysine is replaced by arginine, and a glutamic acid mediated 16 carbon palmitoyl fatty acid side chain is added to the 26th lysine. The mechanism of action of liraglutide is similar to endogenous GLP-1, which binds and activates the GLP-1 receptor - a cell surface receptor Chemicalbook that can activate adenylate cyclase through excitatory G protein Gs coupling. Endogenous GLP-1 has a half-life of 1.5 to 2 minutes and is easily degraded by two widely present endogenous enzymes, dipeptidyl peptidase 4 (DPP-4) and neutral endonuclease (NEP). Compared to natural GLP-1, liraglutide is more stable, with a plasma half-life of 13 hours after subcutaneous administration. This half-life change is attributed to the modification of the structure of liraglutide. Due to the presence of fatty acid side chains, on the one hand, the hydrophobicity of palmitic acid self forms into a heptamer, slowing down the absorption at the subcutaneous injection site; On the other hand, after absorption into the bloodstream, it increases its binding with plasma albumin, forming a slow release reservoir that temporarily avoids contact with endogenous enzymes and slows down release, prolonging the absorption and distribution time in the body, and significantly prolonging the half-life compared to natural GLP-1. Drug interaction with liraglutide can cause delayed gastric emptying time, which may affect the absorption of oral medications taken simultaneously. In clinical pharmacology trials, liraglutide did not affect the absorption of the tested oral drug in terms of clinical relevance. Nevertheless, monitoring the potential consequences of delayed absorption of oral medications taken simultaneously

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Contact Information

Shanghai Ouda New New Material Science and Technology Center´╝îlocated in Fengxian District, Shanghai. The company produces more than 1000 kinds of high-quality products I20 production lines to provide OEM services, as one of the most dynamic industry and trade integrated companies in the Chinese market.our advantage comes from our service, we can provide fast delivery. The average delivery time in peak season is less than 15 working days, and the average delivery time in off-season is less than 1 month. We have successfully transported many chemical raw materials to many countries in the world. Good feedback and repeat orders have supported the growth of our company.independent production lines, we have 20 pharmaceutical raw materials, organic solvents and other raw material production lines. In addition, we also have an API production workshop with independent research and development production lines, as well as an API research and development testing center. We can provide you with sample testing and accept small orders. Supply 99%+ quality chemical products. We believe only good quality can bring good cooperation, quality is our key spirit during our production, we are warmly welcome clients and partner from all over the world contact us for everlasting cooperation, Ouda will be your strong, sincere and reliable partner in China.


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Last Update : Apr 18, 2024 4:56 AM
Number of Views: 12
Item  Owner  : Jan
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