cardarine powder dosage GW 501516 benefits CAS:317318-70-0
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Packing:10g,100g,500g and 1kg
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Product Name: GW501516(Cardarine)
Appearance: white powder
Purity: 99.% min
Package: 10g/bag or as customers’request.
Test Method: HPLC
GW501516, also known as Cardarine, was first developed in 1990, 32 years ago.
GW501516 was originally developed to block the growth of tumors in the colon, prostate and breast. However, when it was first introduced, it was marketed as a drug to control bad cholesterol, or low-density lipoprotein, because during early clinical trials, researchers found that it also affected blood lipid levels in humans.
However, the GW501516 is really known as a bodybuilding aid.
GW501516 increases metabolism and endurance. When used in bodybuilding, it helps the bodybuilder lift heavier weights or train for longer periods of time with faster recovery. It also helps burn excess body fat. It looks like a product aimed for bodybuilding.
By the mid-1990s, the GW501516 was popular with bodybuilders around the world.
GW501516 was subsequently introduced in 2000 as a treatment for hyperlipidemia and entered phase I trials, followed by phase II trials in 2022.
Further development of GW501516 was abandoned for safety reasons in 2007, when preclinical toxicology suggested it could cause cancer.
Possibly carcinogenic, because nuclear hormone activated peroxisome proliferator activated receptor β/δ (PPARβ/δ), possibly carcinogenic, not that GW501516 is directly carcinogenic.
GW501516 is a peroxisome proliferator activated receptor (PPAR) agonist, which is believed to act on the nuclear hormone receptor NHR involved in glucose and lipid metabolism.GW501516 activates AMP-activated protein kinase, glucose uptake, and fatty acid oxidation in skeletal muscle.
Moreover, it is controversial that PPARβ/δ activation is carcinogenic, because in the current studies on PPARβ/δ activation, it is possible that PPARβ/δ activation can both inhibit tumor production and promote tumor proliferation, which may also be related to the dose used. After all, when used for experimental purposes, High doses are often used to verify that they have optimal effects. Currently, research on activation of PPARβ/δ is still ongoing, and perhaps, in the near future, the concern will be answered.
From above,we know that GW501516 is a PPAR agonist, not SARM, but because it has been classified as SARMs by bodybuilder for its similar role.
Although GW501516 has a similar effect to SARMs, PPAR does not bind to androgen receptors and has no anabolic activity, so it does not affect the body’s own testosterone secretion. While it increases endurance, it does not cause difficulty falling asleep or create feelings of anxiety or tension.
GW501516 from the emergence of up to now, has been more than 30 years, is a relatively mature bodybuilding assistance products. GW501516 has a half-life of about 24 hours. It can be used once a day, half in the morning and half in the evening. GW501516 is soluble in water and can be added to drinks.
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